Post-doctoral fellow at University of California San Francisco Medical Center and San Francisco VA
The Cardiac Biomechanics Laboratory at the University of California San Francisco Medical Center (UCSF) Division of Cardiothoracic Surgery and San Francisco VA Medical Center is seeking a hard working, motivated post-doctoral fellow to participate in biomedical engineering research involving the ascending thoracic aortic aneurysms (aTAA). The post-doctoral fellow should be motivated to be on a career track to become an academic professor. Our lab is NIH funded to investigate the biomechanics of aortic aneurysms and currently has 2 postdoctoral fellows, and are seeking a 3rd. The goals are to determine aneurysm aortic wall stress in relationship to aneurysm failure strength. Finite element models will be developed by using in vivo magnetic resonance imaging (MRI) and specimen micro-computed tomography (Micro-CT) for FEA. Specimens will undergo biaxial stretch testing to failure. 4D flow MRI will provide flow input conditions and enable fluid-structure interaction simulations to evaluate wall shear stress contribution. Furthermore, the postdoc will be asked to assist in development of transcatheter aortic valves which treat aortic stenosis with a percutaneous therapy. Our lab has a submitted patent on a new transcatheter aortic valve and we require device prototyping and development. A strong background in computational experience is required. Furthermore, experience in experimental biomechanics using biaxial stretch testing and fluid dynamics using a pulse duplicator is required. The individual would enhace their research experience in a multidisciplinary approach and gain exposure to an academic surgical environment with expected progression to independence as faculty in academics. There is potential opportunity to observe cardiac surgery and learn about the treatment of cardiovascular disease.
The Cardiac biomechanics laboratory has several broad areas of focus, including finite element modeling of the aortic root for transcatheter aortic valves, for the Ross operation, and for ascending thoracic aortic aneurysms. Proof of concept funding has previously been obtained to optimize the transcatheter aortic valve patent leaflet and stent design and study its biomechanics and fluid-structure interactions. R01 funding has been obtained to study ascending thoracic aortic aneurysms, using biomechanics to predict clinical failures and timing of surgical intervention.
Individuals must have prior research experience and preference will be given to those with expertise in advanced mathematical modeling skills, including developing their own code, C++, MatLab, RapidForm, LS-DYNA, ABAQUS. Previous experience with tissue biomechanics is also highly preferred. Interested individuals should send via email: 1)cover letter with short and long term professional goals, 2)copy of undergraduate and graduate transcripts (unofficial copy in MS word format is acceptable), 3)two letters of reference with contact information (email acceptable) and 4)detailed resume. Please send to
elaineetseng@gmail.com.
Essential Functions:
- To determine the material properties of human aortic aneurysms using biaxial stretcher.
- To cryopreserve human aortic tissue for experimentation.
- Develop FE models of patient aTAAs using CT with application of wall thickness from DENSE-MRI.
- Develop FE zero-pressure models of patient aTAAs by inverse modeling.
- Develop FE models of patient aTAA surgical specimens using microCT of zero-pressure geometry.
- Determine aTAA surgical specimen wall thickness, stress-strain curves by biaxial stretch testing, and failure limits by uniaxial failure testing.
- Compare FE models derived from in vivo imaging with those obtained from surgical specimens.
- FEA to compare areas at risk of failure based upon stress vs failure strength.
- To assist in writing grants for funding, analyze and write up research results for publication.
- Present results at national and international meetings.
- Perform other duties as assigned
Job Requirements:
- PhD in Bioengineering, Mechanical Engineering, Computer Science, Mathematics, Engineering
- Experience congruent with educational level
- Skills in biaxial stretching, meshing with Rapidform, finite element modeling with LS-DYNA/Abacus preferred but not essential
- Strong oral and written communication and organizational skills.
Working Conditions/Environment:
Individual works in the Cardiac Biomechanics Laboratory at the San Francisco VA Medical Center affiliated with the University of California San Francisco Medical Center. They are expected to be highly motivated, hard working, and particularly resourceful.
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