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موضوع: موقعیت‌های خالی در دانشگاه‌های خارج از کشور

  1. #11
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    RESEARCHER TEMPORARY


    At the University of Bergen, Department of Biomedicine, there is a temporary position available as Researcher in the project ”Development of anti-cancer drug candidate using biosynthetic and chemical engineering” from January 1st 2010 until March 31st 2012. The position is financed by the Norwegian Research Council. The researcher will be associated with the Translational Signaling Group.
    The project involves the testing of novel anticancer drug candidates from marine microorganisms (provided by partners in Trondheim) for ability to eradicate leukemic cells in vitro and in selected intact organism models of leukemia. The project aims also at elucidating the action mechanism of successful drug candidates.
    The successful applicant must hold a Ph.D. or have similar qualifications in cell biology, molecular biology or a related discipline. The candidate is expected to have experience with or be willing to rapidly learn techniques allowing:
    - culturing of leukemia cells and assessment of their proliferation and death type
    - stable retroviral transfection of leukemia cells
    - advanced fluorescence immune-microscopy of cells
    - relevant rodent experiments
    - gene array and/or proteomics experiments on leukemia cells and their analysis
    The candidate should be able to work independently and interactively in a team setting and be proficient in spoken and written English.
    Additional information on the position available by application to Professor Stein Ove Døskeland,
    Ph. +47 55 58 63 76, e-mail stein.doskeland@biomed.uib.no
    Salary level 57 (code 1109 on the government salary scale, NOK 438 700 pr year, before tax)
    Female applicants are encouraged to apply. If several applicants are equally qualified for the scholarship, the internal rules for gender quotas in the Personnel Rules for scientific positions will be applied.
    State employment shall reflect the multiplicity of the population at large to the highest possible degree. We have therefore adopted a personnel policy objective to ensure that we achieve a balanced age and sex composition and the recruitment of persons of various ethnic backgrounds. Persons of different ethnic backgrounds are therefore encouraged to apply for the position.
    The University of Bergen applies the principles of public openness when recruiting staff to scientific positions.
    The successful applicant must comply with the guidelines that apply to the position at any time.
    The application, which shall include a full and complete overview of all relevant previous experience, is to be sent to www.jobbnorge.no. Applications sent by e-mail will not be considered. Copies of diplomas, scientific work, a list of these (3 copies of all documents), should be sent to University of Bergen, Department of Biomedicine, Box 7804, 5020 Bergen, Norway.
    Closing date for application: 21.11.2009
    The application should be marked:2009 /12480

  2. #12
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    Researcher(temporary)


    At the University of Bergen, Department of Biomedicine, there is a temporary position available as Researcher in the project ”Mesenchymal Stem Cells: Mechanisms of Spontaneous Transformation” from January 1st until December 31st 2010. The position is financed by the Norwegian Research Council.
    The Researcher will be part of the Translational Cancer Research. The focus of the project is to determine effects of lytic peptides on cancer stem-like cells. The successful applicant should hold an MD degree and have experience in studying pharmacologic and therapeutic effects on various cancer models. The candidate should have experience in:
    - Performing toxicological tests in vitro
    - General and clinical pharmacology
    - Peptide chemistry
    - Good knowledge on clinical studies.
    - Clinical experience as a doctor, preferable in surgical disciplines.
    The candidate should be able to work independently and interactively in a team setting and be proficient in spoken and written English.
    Additional information on the position available by application to Professor Rolf Bjerkvig,
    Ph. +47 55 58 63 52, e-mail rolf.bjerkvig@biomed.uib.no
    Salary level 50 (code 1108) on the government salary scale (NOK 387 500 pr year, before tax).
    Female applicants are encouraged to apply. If several applicants are equally qualified for the position, the internal rules for gender quotas in the Personnel Rules for scientific positions will be applied.
    State employment shall reflect the multiplicity of the population at large to the highest possible degree. We have therefore adopted a personnel policy objective to ensure that we achieve a balanced age and sex composition and the recruitment of persons of various ethnic
    backgrounds. Persons of different ethnic backgrounds are therefore encouraged to apply for the position.
    The University of Bergen applies the principles of public openness when recruiting staff to scientific positions.
    The successful applicant must comply with the guidelines that apply to the position at any time.
    The application, which shall include a full and complete overview of all education and previous experience, are to be sent to www.jobbnorge.no Applications sent by e-mail will not be considered. Copies of diplomas, scientific work, a list of these (3 copies of all documents), should be
    sent to University of Bergen, Department of Biomedicine, Box 7804, 5020 Bergen, Norway.
    Closing date for application: 28.11.2009
    The application should be marked: 20009/12280

  3. #13
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    PhD position in Amorphous Alloys for Medical Implants (NT-68/09)


    Applications are invited for a PhD position to work within a new collaboration between The Norwegian University of Science and Technology (NTNU), Trondheim, Norway and The Royal Institute of Technology (KTH), Stockholm, Sweden. Also participating within the project are scientists from Swerea KIMAB AB and the Karolinska Institute, Stockholm, Sweden.

    This project is a new and interdisciplinary initiative funded by NTNU in the area of amorphous alloys for medical implants, and aims to investigate the properties and suitability of these materials for hip prostheses. A range of techniques will be developed and used to study wear and tribocorrosion degradation mechanisms of amorphous alloys. The student will be expected to develop an understanding of the factors influencing behaviour and degradation of amorphous and alloys in contact with polymers in synovial fluids. The student will refine and improve existing wear testing equipment to allow tribocorrosion studies on amorphous alloys. Mechanical design, design of programmable control systems (e.g. using LabView) and electrochemical data-logging will be involved. The project contains both experimental and theoretical work, and allows significant freedom for the student to develop his/her research capability.

    To be eligible students must have or expect to obtain in the near future a master’s or quivalent degree in materials science, physics, engineering or a related subject, and demonstrate a strong academic record. Applications are particularly welcome from candidates with experience in experimental design, programming (e.g. LabView or similar), tribocorrosion, materials science and metallic biomaterials. Candidates should be able to demonstrate a capability to work independently and logically, with an analytical approach to an interdisciplinary project in an international environment. Candidates must demonstrate a capability to express themselves fluently in spoken and written English.

    The primary workplace will be Department of Materials Science and Engineering, NTNU, Trondheim, Norway, but the project will involve some travelling between Trondheim and Stockholm. The appointment of the PhD fellow will be made according to Norwegian guidelines for universities and university colleges and to the general regulations for university employees in Norway.
    Applicants are obliged to engage on an organized PhD training program, and appointment requires approval of the applicant's plan for a PhD study. Their MSc degree results are thus expected to qualify for acceptance as a PhD student at NTNU. The Fellow and the University must sign a mutual contract regarding the period of appointment and the obligations of the PhD fellow.
    NTNU’s PhD-rules require a master degree or equivalent with at least 5 years of studies and an average grade of A or B within a scale of A-E for passing grades (A best). Candidates from universities outside Norway are kindly requested to send a Diploma Supplement or a similar document, which describes in detail the study and grade system and the rights for further studies associated with the obtained degree: http://ec.europa.eu/education/polici...iploma_en.html

    PhD scholarship recipients are employed for three years in the position. The salary is adjusted according to the Norwegian state salary scale at level 45, gross NOK 355 400 a year (before tax) at appointment, with a deduction of 2 % premium for the Norwegian State Pension Fund.

    For further information please contact: Department of Materials Science and Engineering/professor Ragnhild Aune tel +47 73594009. e-mail: ragnhild.aune@material.ntnu.no

    Information on the Department of Materials Science and Engineering, NTNU can be found at http://www.material.ntnu.no

    For information about NTNU and Trondheim, see www.ntnu.no and http://www.trondheim.no/engelsk/.
    Detailed information on our PhD programmes is found at
    http://www.ntnu.no/nt/english/phd or http://www.ntnu.no/studies/phd

    The application must contain information on previous education, exams, and professional experience.

    Applications with CV, certified copies of transcripts and reference letters should be submitted electronically through link on this page. We prefer the attachments in one single file. Publications and other scientific reports that the applicant would like the University to consider, must be scanned and submitted electronically along with the other attachments. Having produced such publications is, however, not a requirement for the PhD position. Joint papers will be considered, but in these cases the candidate should account for her or his contribution.

    The positions reference number is NT-68/09.
    Application deadline: 2009-11-06.

  4. #14
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    PhD position in Cell-Molecular Biology (NT-66/09)


    Cellular and molecular interactions of glucosinolate-derived isothiocyanates

    A PhD position in molecular biology focusing on the cellular and molecular interactions of plant phytochemicals is available at the Department of Biology. The fellowship is for three years with the possibility of a fourth year including 25 % teaching duties to the Department of Biology. The position is within the NTNU Cell and Molecular Biology Group (CMB): (http://boneslab.bio.ntnu.no/index.html) and http://boneslab.bio.ntnu.no/open_positions.html

    The fellowship runs under the doctoral programme at the Faculty of Natural Sciences and Technology. The faculty is the employer, and working place is Department of Biology. For shorter periods the candidate will work at other NTNU Departments. The Department of Biology has 36 members of faculty (professors and associate professors), 22 research scientists and about 66 PhD students and post docs.

    The department has research programs in evolutionary biology, population genetics, aquatic and terrestrial ecology, conservation biology and biodiversity, ethology, molecular biology, cell biology, plant and animal physiology and ecophysiology, aquaculture, and marine biology. There is considerable collaboration between the disciplines. More information about the Department of Biology can be found at: http://www.ntnu.no/biologi/english.

    Project background:
    Plant phytochemicals comprise well known pharmaceuticals and antioxidants like salicylic acid, phenolics, coumarin, flavonoids, digitalis and cyanogenic glycosides, that constitute binary enzyme glucoside systems. They are stored as hydrophilic and inactive prodrugs, and released as lipid soluble aglycones, a principle also used in synthetic drugs. A group of aglycones from glucosinolates, naturally found in cabbage and broccoli, are commonly known as cancer chemopreventive agents; in the human diet found epidemiologically to be anti-carcinogenic. These compounds can both prevent the development of precancerous cells but also selectively trigger cell-death in malignant cells. In many organisms changes in redox status is linked to defence, immune responses and cell death. In mammalian cell-cultures glucosinolate derived aglycones has been shown to have redox-mediated properties that can inhibit carcinogenesis, and alter gene expression through the modulation of thiols and depleting glutathione, but also affect the cell cycle and induce apoptosis.

    Considering the importance of these compounds in both human diet, and in the plants themselves, we have for many years investigated the enzyme-system responsible for aglycone release in plants. In Arabidopsis and Brassica plants this system has largely been explored in pathogen and insect defence, both systemically and locally. Rapid release of potent and toxic metabolites occurs when tissue integrity is compromised. The toxic aglycones are reactive sulphur species; isothiocyanates and derivatives that potentially can modulate several cellular targets in-vivo; cytoskeleton, mitochondria, ion channels, and gene-expression, a largely unexplored view of their effects.

    The PhD project aims to investigate the interaction of isothiocyanates in both; plants and mammalian cells including laboratory animals, to find common mechanisms of action, with particular emphasis on cell-death, apoptosis, senescence and the cytoskeleton. This will be done by a variety of methods and state-of the art equipment in gene expression profiling and confocal microscopy.

    Requirements:
    The positions require a Master degree or similar within molecular biology and/or cell biology, alternatively; biotechnology, toxicology/pharmacology or biochemistry. The applicant must be qualified for the doctoral program within these disciplines. Experience from work on Arabidopsis/Brassicas is an advantage, but not an absolute requirement. Candidates with knowledge of one or more of the following methods and techniques will be considered advantageous; animal or plant cell-culture (transfection and transformation), microscopy (confocal and EM), gene expression profiling/DNA-microarray, research-animal certificate (or experience). We will put emphasis on composing a research team with complementary skills, where competence in cell and molecular biology is essential.

    We are looking for a hard-working candidate, highly motivated to conduct fundamental scientific research. Ability to carry out goal-oriented work, ability to deliver, oral and written presentation of research results, and good co-operation abilities will be emphasized.

    In order to be accepted as a PhD student the grades of the MSc degree has to be sufficiently high (in Norway: B/2.5, or better), or the applicant has to document a similar level through later scientific work. Candidates from universities outside Norway are requested to send a Diploma Supplement or a similar document, which describes in detail the study and grade system and the rights for further studies associated with the obtained degree: http://ec.europa.eu/education/policies/rec_qual/recognition/diploma_en.html

    The application must contain information on education, exams and previous practice. Publications and other scientific work which the applicant wishes to be taken into consideration must be attached. Multi-authored publications require a brief description of the applicant’s contribution, and should be enclosed.

    The appointment of the PhD fellow will be made according to national guidelines for appointment of PhD fellows at universities and university colleges. Applicants are obliged to engage in an organized PhD training program, and an educational plan will be drafted that includes the attendance of courses and national/international meetings. The PhD student will also be expected to assist in the teaching of undergraduates.

    A contract regarding the period of appointment and the obligations of the PhD fellow must be signed by the fellow and the University. Appointment requires approval of the applicant's plan for a PhD study, and should lead to a dissertation (PhD thesis).

    The appointment will be made according to the general regulations regarding university employees. The government work force of Norway should reflect the diversity of the population, and this is an «Equal Opportunities position».

    The annual salary of the PhD position is NOK 355.400,- per year (code 1017, level 45 according to the government pay-scale for university employees). There is 2% deduction for superannuation.

    Questions regarding the position can be directed to:
    Associate Professor Ole Petter Thangstad (ole.thangstad@bio.ntnu.no) tlf. +47 73 59 60 96.

    Within the application deadline, applicants should submit the application, a CV, certified copies of certificates of education and other relevant documents, names of three references with e-mail addresses and phone number.

    Applications should be sent electronically through this page. Preferably, we want the attachment in one file. Application deadline: 06.11.2009. Reference number: NT-66/09.

  5. #15
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    PhD student position in Biotechnology


    Reference number 2009/164
    Apply for this job

    Application deadline 2009-12-04
    The newly-created Wallenberg Wood Science Center is seeking PhD students and postdoctoral scientists to engineer functionalities of wood components and create new generation of sustainable materials based on wood polymers.
    Wallenberg Wood Science Center is a joint research center established with KTH, Royal Institute of Technology, Stockholm, Sweden and Chalmers University of Technology, Gothenburg, Sweden, as participants. The annual budget exceeds 40 MSEK and at least 50 people will participate.
    The objective is underpinning materials research for utilization of our forests in new products, such as ”green” polymers and biocomposite materials. The tree is viewed as a source of chemicals, monomers, biopolymers and fibers. Recent advances in nanotechnology, polymer science, biotechnology and mechanics are being combined with established forest products technologies in a new multidisciplinary research center located in Stockholm and in Gothenburg.


    Job description This project will be in enzymatic and chemical modifications of wood polymer; hemicelluloses. Focus will be on thermoplastic derivatives of soft and hardwood xylans for use as binder in new generation of biocomposites.
    The position is limited to maximum five years and corresponds to full-time research studies during four years. In addition, teaching in the undergraduate or masters curriculi at Chalmers could be included corresponding to one year, teaching work distributed over the whole time of the position.
    The candidate will be working at the Department of Chemical and Biological Engineering at Chalmers University of Technology.


    Qualifications The successful candidate will have a MSc in Chemical or Biological engineering or Biochemistry. Candidate with experience of work with enzymes and material characterization is preferred. Fluency in English, both written and verbal, is a must.
    We are looking for quality-conscious candidates with an innovative way of thinking. You are a persistent person who has problem-solving analysis skills and most important, you are able to work well with other people.



    Application procedure The application shall be written in English and include the following items:
    1. An application of a maximum of one A4 page containing your specific qualifications for the position
    2. Attested copies of education certificates, including grade reports and other documents
    3. Curriculum Vitae
    4. Letters of recommendation and name of reference persons (optional)
    The application shall be sent electronically as pdf or zipped documents. Please use the button at the foot of the page to reach the application form.
    If any material is not available electronically or cannot be transferred to pdf format, the material can be sent as a hard copy to Registrar. The applicants name and the reference number (2009/164) must be written on the first page of the application.
    Address:
    Registrar
    Chalmers University of Technology
    SE-412 96 Göteborg
    Sweden

    Further information For further information, please contact
    Professor Paul Gatenholm, Biopolymer Technology paul.gatenholm@chalmers.se and
    Professor Lisbeth Olsson, Industrial Biotechnology lisbeth.olsson@chalmers.se



    Union representatives
    • SACO: Jan Lindér
    • ST: Marie Wenander
    • SEKO: Johan Persson
    All reachable via Chalmers exchange: +46 31 772 10 00





    روزگار است، آنكه گه عزت دهد گه خوار دارد. چرخ بازيگر از اين بازيچه ها بسيار دارد. "قائم مقام فراهانی"

  6. #16
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    Applications are invited for a Research Associate (post-doctoral) to join a team of investigators in the Department of Physiology at the University of Arizona led by John P. Konhilas, Ph.D. The candidate will also be part of the Molecular Cardiovascular Research Program and the Sarver Heart Center. Specific studies investigate the mechanisms underlying the impact of sex/gender, disease and exercise on molecular and cellular biology of the heart and how it affects cardiac contractile function and myocellular signaling. The candidate should have profound knowledge of molecular and cellular biology and biochemistry, possess and maintain technical skills in multiple areas including molecular cloning and protein expression systems using both prokaryotic and eukaryotic organisms, cell and tissue culture. Experience with adeno-viral or adeno-associated viral technology is highly desirable but not required. Candidates must be willing to work independently as well as in a team setting.

    Further requirements for the position include the ability to:
    • Design and implement research projects relevant to the focus of the lab
    • Carry out experiments and help interpret the data
    • Work in a collaboration with other lab members
    • Actively participate in seminars, journal clubs and lab meetings
    • Mentor undergraduate, graduate students

    Outstanding UA benefits include health, dental, and life-insurance, paid vacation sick leave and holidays. UA/ASU/NAU tuition reduction for employee and qualified family members, access to recreation and retirement. The post is available as soon as possible and will continue indefinitely.
    Applicant must hold a doctoral degree (Ph.D., DVM, or MD in closely related field). Additional minimum requirements include demonstrated productivity through publications and eligible to apply for NIH career development awards. Salary and benefits will be commensurate with experience and in accordance with NIH guidelines. Submit a letter of application indicating research interests, career goals, a curriculum vitae, and the names with contact information of two references to:

    John P. Konhilas, Ph.D.
    University of Arizona
    PO Box 245051
    1656 E Mabel St
    Tucson, AZ 85724
    روزگار است، آنكه گه عزت دهد گه خوار دارد. چرخ بازيگر از اين بازيچه ها بسيار دارد. "قائم مقام فراهانی"

  7. #17
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    پیش فرض پاسخ : موقعیت‌های خالی در دانشگاه‌های خارج از کشور

    Research Associate and Postdoctoral Research Fellow
    The Department of Cellular & Physiological Sciences at the University of British Columbia invites applications for a Research Associate and/or Postdoctoral Research Fellow in the field of Pancreatic Cancer. Our research group is dedicated to improving our understanding of disease mechanisms from the cellular level up to the integrated systems physiology level. The group has recently obtained pilot funding to expand ongoing studies on the role of hyperinsulinemia and insulin signalling in pancreatic cancer, as well as links between pancreatic cancer and diabetes.

    The Laboratory for Molecular Signalling is looking for extremely motivated post-doctoral fellows or research associates to join a dynamic, well-funded laboratory. We are part of the Diabetes Research Group (http://www.diabetes.ubc.ca/JJpage.htm), located at the Life Sciences Institute (http://www.lsi.ubc.ca/), at the University of British Columbia (www.ubc.ca) in Vancouver, Canada. Our laboratory studies many aspects of pancreatic cell fate and function. We employ a range of experimental approaches from single-cell imaging, to molecular biology, to in vivo studies on genetically engineered mice. Of particular interest are the mechanisms of insulin signalling. The laboratory is fully equipped for molecular biology, in vivo mouse studies, and a wide variety of single-cell imaging/physiology modalities (3D multi-channel imaging with deconvolution; FRET; FLIM-FRET; TIRFM; microinjection, flash photolysis). We also have access to numerous Core facilities within the Life Sciences Institute including FACS, and high-throughput/high-content imaging for screening. The Life Sciences Institute is also home to the UBC Centre for Disease modeling where in rodent studies can be conducted to understand the progression of pancreatic cancer in vivo. The laboratory is located within an extremely collaborative group and the potential for working together with other research teams is high.
    Ideal applicants should possess strong CVs with multiple publications in fields related to pancreatic cancer, diabetes and/or signal transduction and show the potential for obtaining external salary support. Please also provide a detailed cover letter clearly stating your career goals and the types of studies you see yourself performing in our laboratory. Address the cover letter, with your CV, and contact information for three references to: Dr. James D. Johnson, Ph.D. james.d.johnson@ubc.ca), no later than November 30, 2009.

    Salary will be commensurate with qualifications and experience. UBC hires on the basis of merit and is committed to employment equity. We encourage all qualified persons to apply; however, Canadians and permanent residents of Canada will be given priority.
    روزگار است، آنكه گه عزت دهد گه خوار دارد. چرخ بازيگر از اين بازيچه ها بسيار دارد. "قائم مقام فراهانی"

  8. #18
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    PhD student position in Physiological Botany

    at the Evolutionary Biology Centre, the Department of Physiological Botany (http://www.ebc.uu.se) announces a PhD student position in the project “The role of the Arabidopsis HETEROCHROMATIN PROTEIN1 in plant development”.
    In plants as well as in animals the control of chromatin structure in response to endogenous and exogenous cues determines gene expression patterns that regulate cell differentiation and development. The available project focuses on an Arabidopsis mutant, terminal flower2 (tfl2). The gene encodes the plant HETEROCHROMATIN PROTEIN1 (HP1), a homologue to the Drosophila HP1 genes that are involved in basic processes as DNA replication, recombination and repair but also in epigenetics and gene activation/repression during differentiation. The single copy gene in Arabidopsis encodes a protein most similar to HP1 proteins that regulate gene activation/ repression in other organisms and it has been shown to localize to euchromatic regions of the chromosomes. Mutations in tfl2 have a pleiotropic effect indicating a global role, possibly regulating different developmental processes in response to light. Our data points to the importance of TFL2 in two phase-transitions during the plant life cycle: embryo – postembryonic development as well as vegetative – reproductive development. Recent results show that TFL2 physically interact with proteins in hormone signal transduction pathways as well as chromatin of both hormone biosynthesis and response genes. The successful candidate will collaborate with another PhD student in this area of hormone regulation of plant development.
    The successful candidate should have a university degree in biology, favourably with the combination of plant biology and molecular biology. The application should include personal background including a description of undergraduate training, a complete CV, copies of university degree and degree thesis as well as the names and e-mail addresses to two referees.
    The PhD position is full time employment position for a tenure of four years. However, the possibility for the tenure to be extendable to a maximum of five years exists to allow the inclusion of university level biology teaching and/or laboratory supervision into the PhD education.
    For more information please contact Dr Annika Sundås-Larsson, that will function as the supervisor, by e-mail annika.sundas-larsson@ebc.uu.se or by phone +46-18-4712819. Union representatives are Anders Grundström, SACO-rådet, tel: +46 18-471 5380, Carin Söderhäll, TCO/ST, tel: +46 18-471 1996 and Stefan Djurström, SEKO, tel: +46 18-471 3315.
    The application should be sent , preferrably by e-mail to: registrator@uu.se, or by fax + 46 18 471 2000, or by mail to: Registrar´s Office, Uppsala University, Box 256, SE-751 05 UPPSALA, Sweden. In any correspondence, please use the reference number UFV-PA 2009/2423. Application no later than 16 November, 2009.
    روزگار است، آنكه گه عزت دهد گه خوار دارد. چرخ بازيگر از اين بازيچه ها بسيار دارد. "قائم مقام فراهانی"

  9. #19
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    پیش فرض پاسخ : موقعیت‌های خالی در دانشگاه‌های خارج از کشور

    Postdoctoral Research Fellows in HIV Desease
    Northwestern University
    Chicago, Illinois, United States
    Post-doctoral research fellow positions are available to characterize the human microbiota and analyze its role in HIV disease. This project will use a metagenomic approach to the analysis of genetic material derived from microbial communities. Candidates are sought with prior experience in microbiology and molecular biology. Review of applications will begin immediately and will continue until the positions are filled or the search is closed. Please send curriculum vitae and three references to: Prof. Steven Wolinsky, Northwestern University Feinberg School of Medicine, Lurie 9-200, 303 E Superior, Chicago, IL 60611 or via email to: s-wolinsky@northwestern.edu Northwestern University is an Affirmative Action, Equal Opportunity Employer. Women and minorities are encouraged to apply. Hiring is contingent upon eligibility to work in the United States.
    روزگار است، آنكه گه عزت دهد گه خوار دارد. چرخ بازيگر از اين بازيچه ها بسيار دارد. "قائم مقام فراهانی"

  10. #20
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    پیش فرض پاسخ : موقعیت‌های خالی در دانشگاه‌های خارج از کشور

    Prediction and characterization of Mycobacterium small RNAs

    50000403v1611
    Promoter: Kathleen Marchal


    Description: Prediction and characterization of Mycobacterium small RNAs

    Promotors: collaborative effort
    K. Marchal: KUL
    A. Sonawane: IIT; avinash.sonawane@imbv.uio.no


    Introduction
    Mycobacterium is a genus of Actinobacteria that include some species of great medical and economic importance, such as Mycobacterium tuberculosis, M. leprae, M. avium, and M. bovis, that are responsible for severe diseases in human and animals. An initial characterization of certain gene clusters on the genomes of Mycobacteria identified several regions to be highly conserved.
    Proteins were long regarded as key regulators of the control of bacterial gene expression, however, the recent discoveries have shown that small RNAs (sRNAs) also play central role in regulating the functions of diverse genes. The search for new sRNAs have traditionally focused on Salmonella and E. coli, however, according to our knowledge much less attention has been diverted to other medically important pathogens including Mycobacterium. The only human pathogen that has received any attention is the Pseudomonas aeruginosa. In 2006 an elegant study by Livny J et al. (1) has identified 17 sRNAs in P. serugionosa genome and predicted several sRNA-encoding genes in 10 diverse pathogens.

    Objectives
    1. Search for sRNAs in Mycobacterium tuberculosis and M. smegmatis genomes
    The main objective of this study is to: in silico prediction of sRNA genes in pathogenic M. tuberculosis and a non-pathogenic M. smegmatis genomes. A variety of approaches (reviewed by Vogel and Shama, 2005) for the genome-wide identification of chromosomally encoded sRNAs have been developed. Based on these knowledge we will take biocomputational approach to identify mycobacteria-specific sRNAs.

    2. Prediction of sRNA targets
    In silico prediction of sRNA targets has successfully been applied in prokaryotes. These predictions are made on the basis of sequence complementarity between sRNA and its target mRNA. Using similar approach the target genes will be predicted. Biocomputationally identified potential targets will be validated by the wet lab experiments. For this the sRNA will be overxpressed using suitable vector and degradation of its targeted mRNA transcripts will be validated using microarray approach. Furthermore, mechanisms of regulation of target genes by sRNAs will be studied in detail.

    3. Functional characterization of the identified targets
    Interesting target genes related to bacterial virulence, intracellular survival and induction of innate immune responses will be functionally characterized.


    Key words: bioinformatics, systems biology, sRNA, microbiology

    Latest application date: 2009-12-21

    Financing: Erasmus Mundus External Cooperation Window

    Type of Position: scholarship

    Duration of the Project : 4 years


    Research group: Department of Microbial and Molecular Systems (M#S)

    Remarks: This project would fit in Lot 13, collaboration with India and requires a collaborative effort between KUL (bioinformatics analysis) and wet lab (group of A. sonawane). The work would be partim in the KUL partim in India.

    روزگار است، آنكه گه عزت دهد گه خوار دارد. چرخ بازيگر از اين بازيچه ها بسيار دارد. "قائم مقام فراهانی"

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